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Coreg is used for treating high blood pressure and congestive heart failure. It is related to labetalol (Normodyne, Trandate). Coreg blocks receptors of the adrenergic nervous system, the system of nerves in which epinephrine (adrenalin) is active. Nerves from the adrenergic system enter the heart and release an adrenergic chemical (norepinephrine) that attaches to receptors on the heart's muscle and stimulates the muscle to beat more rapidly and forcefully. By blocking the receptors, coreg reduces the heart's rate and force of contraction and, thereby, reduces the work of the heart. Coreg also blocks adrenergic receptors on arteries and causes the arteries to relax and the blood pressure to fall. The drop in blood pressure further reduces the work of the heart since it is easier to pump blood against a lower pressure. Do not stop using this drug without first consulting your doctor. Your condition may become worse when the drug is suddenly stopped, especially if you have chest pain (angina) or heart disease (e.g., coronary artery disease, ischemic heart disease, heart failure, high blood pressure). If your doctor decides you should no longer use this drug, you must gradually decrease your dose according to your doctor's instructions. When gradually stopping this medication, it is recommended that you temporarily limit physical activity to decrease strain on the heart. Seek immediate medical attention if you develop: worsening chest pain, tightness or pressure in the chest, chest pain spreading to the jaw|neck|arm, sweating, trouble breathing or fast|irregular heartbeat. Before taking coreg, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: asthma, certain types of irregular heartbeats (e.g., sinus bradycardia, second or third degree atrioventricular block), cardiogenic shock, severe heart failure (overt or decompensated type), liver disease. Before using this medication, tell your doctor or pharmacist your medical history, especially of: other breathing problems (e.g., chronic obstructive lung disease), other heart problems (e.g., Prinzmetal's variant angina), diabetes, overactive thyroid disease (hyperthyroidism), kidney disease, blood circulation problems (e.g., Raynaud's disease), skin conditions (e.g., psoriasis), mental|mood disorders (e.g., depression), a certain type of tumor (pheochromocytoma), certain muscle disease (myasthenia gravis). Before having surgery, tell your doctor or dentist that you are taking this medication. If you have diabetes, this medication may mask the fast|pounding heartbeat you would usually feel when your blood sugar level falls too low (hypoglycemia). Other symptoms of a low blood sugar level such as dizziness or sweating are unaffected by this drug. This drug may make you dizzy, drowsy, or faint, especially when you first start using this drug or if your doctor increases your dose. Use caution engaging in activities requiring alertness such as driving or using machinery. The manufacturer recommends avoiding these activities during periods of adjustment in your dose. Limit alcoholic beverages. To minimize dizziness and lightheadedness, get up slowly when rising from a seated or lying position. Taking this medication with food will also help decrease these effects. Caution is advised when using this drug in the elderly because they may be more sensitive to its effects, especially dizziness and lightheadedness. This medication should be used only when clearly needed during pregnancy. Discuss the risks (e.g., low birth weight) and benefits with your doctor. Based on information from related drugs, this medication may pass into breast milk. Therefore, consult your doctor before breast-feeding.

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